Level of scientific proof provided by the literature (for clinical studies) | Recommendation grading |
---|---|
Level 1 | Level A |
- High-power randomised comparative studies | Scientific proof established |
- Meta-analysis of randomised comparative studies | |
- Decision analysis based on well-conducted studies | |
Level 2 | Level B |
- Low-power randomised comparative studies | Scientific proof presumed |
- Well-conducted non-randomised comparative studies | |
Level 3 | Level C |
- Case–control studies | Low level of proof |
Level 4 | Level D |
- Comparative studies with major bias | Expert consensus |
- Retrospective studies | |
- Case series |