Study | Lung cancer + | Lung cancer - | Total | Results |
---|---|---|---|---|
Initial screening in 1996 | Detection rate 0.4 % | |||
CT + | 25 | 305 | 330 | Sensitivity 57 % |
CT - | 19 | 5965 | 5984 | Specificity 95 % |
Total | 44 | 6270 | 6314 | Predictive value 8 % |
First annual repeat in 1997 | Detection rate 0.6 % | |||
CT + | 28 | 169 | 197 | Sensitivity 85 % |
CT - | 5 | 4823 | 4828 | Specificity 97 % |
Total | 33 | 4992 | 5025 | Predictive value 14 % |
Second annual repeat in 1998 | Detection rate 0.2 % | |||
CT + | 9 | 164 | 173 | Sensitivity 100 % |
CT - | 0 | 4867 | 4867 | Specificity 97 % |
Total | 9 | 5031 | 5040 | Predictive value 5 % |
Henschke et al, 1999 [19] | ||||
Initial screening | Detection rate 2.7 % | |||
CT + | 27 | 206 | 233 | Sensitivity 100 % |
CT - | 0 | 767 | 767 | Specificity 79 % |
Total | 27 | 973 | 1000 | Predictive value 12 % |
First annual repeat | Detection rate 0.6 % | |||
CT + | 6 | 24 | 30 | Sensitivity 100 % |
CT - | 0 | 970 | 970 | Specificity 98 % |
Total | 6 | 994 | 1000 | Predictive value 20 % |
Vehmas et al, 2000 [20] | ||||
Initial screening | Detection rate 0.8 % | |||
CT + | 5 | 60 | 65 | Sensitivity 100 % |
CT - | 0 | 537 | 537 | Specificity 90 % |
Total | 5 | 597 | 602 | Predictive value 8 % |