Systematic Review of the Effects of Asbestos Exposure on the Risk of Cancer between Children and Adults

Table 2 The relationship between age at first asbestos exposure and mesothelioma

Study (Type of risk)	Age at first exposure	Risk	95% CI ^a
Chen M (2012) [22] (SMR^b)	< 20 years	5,556.19	2,872.6-9,723.3
Chen M (2012) [22] (SMR^b)	≥ 20 years	7,494.63	2,428.3-17,462.5
Lacourt A (2012) [23] (OR^c)	15 years^d	12.3	9.0-16.9
	20 years^d	6.5	6.1-6.9
	30 years^d	1.8	1.1-3.0
Rake C (2009) [24] (OR^c)	< 20 years^e	9.2	6.4-13.1
	20-29 years^e	3.1	1.9-5.0
	≥ 30 years^e	1.7	0.7-3.9
Pira E (2007) [25] (SMR^b)	< 25 years	7,968	Does not include 100
	25-34 years	4,828	Does not include 100
	≥ 35 years	2,085	Does not include 100
Reid A (2007) [26] (Hazard ratio)	< 15 years	1.00
Reid A (2007) [26] (Hazard ratio)	≥ 15 years	3.88	2.2-6.8
Luce D 2000 [27] (OR^c)	Birth	52.8	6.5-427
	< 20 years	20.0	1.1-368
	≥ 20 years	0.0

^a CI Confidence intervals.
^b SMR Standardized Mortality Ratio.
^c OR Odds Ratio.
^d One category of age at first exposure has different total duration of exposure which is 10, 20, 30 and 40 years. For making a comparison, 40 years of total duration of exposure was used, which shows the highest OR among those years.
^e One category of age at first exposure has different duration of employment which is < 5, 5–9, 10–19. ≥ 20 years and total. But for simple comparison, just data in total category of duration of employment were used. When the analysis are restricted to domestic exposure SMR among exposed male before under age 30 is 2.1 (95% CI 1.0-4.5) than age over 30, and it of exposed female before under age 30 is 1.9 (95% CI 1.1-3.2).

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