Subclinical interstitial lung damage in workers exposed to indium compounds

Table 5 Dose–response relations between serum indium and KL-6, SP-D, and interstitial changes on chest HRCT

	Serum indium (μg/L)			KL-6 (U/mL)		SP-D (ng/mL)		Prevalence (%)
Group	Range	GM	n	GM	GSD	GM	GSD	KL-6 (>500 U/mL)	SP-D (>110 ng/mL)	HRCT-I
0	<1.0	0.2	3	586.1	1.3	120.9	2.9	100.0	33.3	0.0
1	1.0-4.9	3.4	7	509.6	1.7	143.8	1.5	42.9	71.4	14.3
2	5.0-9.9	7.4	6	1126.9	1.6	132.5	1.6	83.3	66.7	33.3
3	10.0-29.9	15.5	6	486.3	1.4	157.6	1.6	50.0	83.3	16.7
4	30.0-49.9	43.8	5	1539.4^*	1.5	252.6	1.9	100.0	80.0	40.0
5	≧50	81.5	7	1451.1^*	1.1	299.8	1.3	100.0	100.0	42.7
p for trend				0.0055		0.0005		0.1057	0.0353	0.1198

Abbreviations: GM geometric mean, GSD geometric standard deviation, KL-6 Krebs von den Lungen-6, SP-D surfactant protein D, HRCT-I interstitial changes on HRCT, Prevalence (%): % of workers exceeding each reference values and % of workers with interstitial changes on HRCT, p for trend: age- and smoking-adjusted multiple regression model for GM and GSD of KL-6 and SP-D, Mantel-Haenszel trend for prevalence data, * P < 0.05 by Dunnett’s test.

ISSN: 2052-4374