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Table 5 Dose–response relations between serum indium and KL-6, SP-D, and interstitial changes on chest HRCT

From: Subclinical interstitial lung damage in workers exposed to indium compounds

  Serum indium (μg/L) KL-6 (U/mL) SP-D (ng/mL) Prevalence (%)
Group Range GM n GM GSD GM GSD KL-6 (>500 U/mL) SP-D (>110 ng/mL) HRCT-I
0 <1.0 0.2 3 586.1 1.3 120.9 2.9 100.0 33.3 0.0
1 1.0-4.9 3.4 7 509.6 1.7 143.8 1.5 42.9 71.4 14.3
2 5.0-9.9 7.4 6 1126.9 1.6 132.5 1.6 83.3 66.7 33.3
3 10.0-29.9 15.5 6 486.3 1.4 157.6 1.6 50.0 83.3 16.7
4 30.0-49.9 43.8 5 1539.4* 1.5 252.6 1.9 100.0 80.0 40.0
5 50 81.5 7 1451.1* 1.1 299.8 1.3 100.0 100.0 42.7
p for trend     0.0055   0.0005   0.1057 0.0353 0.1198
  1. Abbreviations: GM geometric mean, GSD geometric standard deviation, KL-6 Krebs von den Lungen-6, SP-D surfactant protein D, HRCT-I interstitial changes on HRCT, Prevalence (%): % of workers exceeding each reference values and % of workers with interstitial changes on HRCT, p for trend: age- and smoking-adjusted multiple regression model for GM and GSD of KL-6 and SP-D, Mantel-Haenszel trend for prevalence data, * P < 0.05 by Dunnett’s test.