From: IgA nephropathy in a laboratory worker that progressed to end-stage renal disease: a case report
Author(s) (year) | Study design | Subjects | Outcome | Period | Population Total GNa/IgAN | Resultse |
---|---|---|---|---|---|---|
Porro et al. [10] (1992) | case–control study | 60 biopsy-proven chronic GNa patients in a University hospital in Italy (including 27 IgAN patients) | onset of IgAN | 1987–1990 | 60/27 (reference:120) | ·An increased risk of IgAN was found for occupational solvent exposure group. ·RRb of IgAN for occupational solvent exposure ; 4.25 (1.18–16.36) |
Stengel et al. [11] (1995) | case–control study | 298 biopsy-proven GNa patients in 5 hospitals in Paris (including 116 IgAN patients) | aggravation of IgAN to CRF | 1989–1991 | 298/116 (reference:298) | ·Among males, clear association was observed between CRF and high exposure to solvents for IgAN; ORc = 3.5 (1.0–11.8), P < 0.05. ·The OR increased with duration of exposure; OR = 5.6 (1.3–24.1) for ≥10 years exposure, (P = 0.02). ·No relationship was observed for cases without CRF. |
Wakai et al. [29] (1999) | case–control study | 94 biopsy-proven IgAN patients in medical centers in Japan | onset of IgAN | 1997–1999 | 94/94 (reference:185) | · Work-related exposure to organic solvents was found not to be associated with the risk for IgAN; OR = 0.55 (0.27–1.12), (P < 0.10) |
Jacob et al. [12] (2007) | retrospective cohort study | 338 non-ESRD patients in Paris (including 194 IgAN patients with biopsy confirm) | aggravation of IgAN to ESRD | 2002–2004 | 338/194 | ·Solvent exposure was associated with faster progression of IgAN to ESRD, HRd for IgAN is 2.6 (1.3–5.5) for high exposure versus none (p < 0.05). ·There was a trend increasing HR with exposure duration before and its persistence after diagnosis. |
Jacob et al. [13] (2007) | retrospective cohort study | 269 patients with non-ESRD and biopsy-proven primary GNa diagnosis between 1994 and 2001 in Paris and suburbs (including 167 IgAN patients) | aggravation of IgAN to ESRD | 2002–2004 | 269/167 | ·This study showed the potential role of toluene and xylene, some petroleum products, ketones and possibly dichloromethane in the progression of GNa to ESRD. |