Table 1 Cohort studies of HBV surface antigen (HBsAg)-seropositive people for the development of HCC
Authors(Years), Country | Cohort description | No. of cases of HCC | Result RR(95% CI) |
|---|---|---|---|
Evans et al. (1998) [42] Senegal | Men in Senegalese Army, 2611 HBsAg+ / 10,425 HBsAg- | 14 | NR |
Nomura et al. (1996) [43] Hawaii, USA | Men of Japanese ancestry (born 1900–1919), 7498 HBsAg+ | 28 | 43.0 (5.7–325.5) |
Chang et al. (1994) [33] Taiwan, China | Men (30–85 years), NR HBsAg+ 38 HCC(24HBsAg+) 152 controls (10 HBsAg +) | 24 HBsAg+ 14 HBsAg- | 26.48 (7.92–88.56) Excluding HCV+ 44.57 (10.17–195.30) |
Lu et al. (1998) [34] Qidong, China | Men (20–60 years), 737 HBsAg+ 699 HBsAg- | 47 | 11.61 |
Yang et al. (2002) [35] Taiwan, China | Men (30–65 years), 2361 HBsAg+ (1991 HBsAg+/HBeAg-) (370 HBeAg+/ HBeAg+) 9532 HBsAg-/HBeAg- | 82 50 32 29 | [11.51 (7.54–17.57)] 9.6 (6.0–15.2), 60.2 (35.5–102.1) 1.0 |
Evans et al. (2002) [36] Haimen City, China | Men and women (25–64 years), Men 8795 HBsAg+ 49,659 HBsAg- Women 2711 HBsAg+ 22,629 HBsAg- | 643,257 61 16 | 18.8 (16.0–22.1) Adjusted for other factors 33.2 (17.0–65.0) Adjusted for other factors |
Wang et al. (2003) [37] Taiwan, China | Men (30–65 years), 2416 HBsAg+ 9421 HBsAg- |  | 13.1 (8.6–20.1) |
Tanaka et al. (2004) [38] Osaka, Japan | Blood donors (men and women 40–64 years), 2519 HBsAg+/ HCV- 1927 HCV+/ HBsAg- 25 HCV+ /HBsAg+ 150,379 HCV−/ HBsAg- |  | 74 (45–121) 36 (21–62) 161 (46–557) 1.0 Adjusted for sex, age, ALT level and cholesterol level. |
Gwack et al. (2007) [39] Korea | Men and women 30 +, HBsAg+ 296 HBsAg- 6582 | 10 26 | [9.6 (4.7–19.9)] |
Amin et al. (2006) [44] Australia | People notified as HBV or HCV positive to NSW State Health Department, All 39,109 HBsAg 75,834 HCV 2604 HBV/HCV Men 20,808 HBsAg 47,903 HCV 1932 HBV/HCV Women 18,301 HBsAg 27,931 HCV 672 HBV/HCV | 124,143 6 105,101 5 19 42 1 | 30.6 (25.7–36.5) 22.5 (19.1–26.5) 30.3 (13.6–67.5 30.6 (25.3–37.1) 18.7 (15.4–22.7) 27.5 (11.4–65.9) 30.7 (19.6–48.1) 44.0 (32.6–59.6) 64.2 (9.0–455.8) |
Crook et al. (2003) [40] England and Wales | Blood donors, 2681 HBsAg+ men 977 HBsAg+ women National population rates as comparator | 20 1 | 26 (16.0–40.5) 10 (NR) |
Ribes et al. (2006) [41] Spain | Blood donors, 1656 HBsAg+ men 631 HBsAg+ women 8783 HBsAg-men 6721 HBsAg-women | 14 1 NR NR | 14.1 (7.7–23.6) 1.5 (0.02–8.29) |