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Table 1 Cohort studies of HBV surface antigen (HBsAg)-seropositive people for the development of HCC

From: Recognition criteria for occupational cancers in relation to hepatitis B virus and hepatitis C virus in Korea

Authors(Years), Country Cohort description No. of cases of HCC Result RR(95% CI)
Evans et al. (1998) [42] Senegal Men in Senegalese Army,
2611 HBsAg+ / 10,425 HBsAg-
14 NR
Nomura et al. (1996) [43]
Hawaii, USA
Men of Japanese ancestry (born 1900–1919),
7498 HBsAg+
28 43.0 (5.7–325.5)
Chang et al. (1994) [33]
Taiwan, China
Men (30–85 years), NR HBsAg+
38 HCC(24HBsAg+)
152 controls (10 HBsAg +)
24 HBsAg+ 14 HBsAg- 26.48 (7.92–88.56)
Excluding HCV+
44.57 (10.17–195.30)
Lu et al. (1998) [34]
Qidong, China
Men (20–60 years),
737 HBsAg+ 699 HBsAg-
47 11.61
Yang et al. (2002) [35]
Taiwan, China
Men (30–65 years),
2361 HBsAg+ (1991 HBsAg+/HBeAg-) (370 HBeAg+/ HBeAg+)
9532 HBsAg-/HBeAg-
82 50 32 29 [11.51 (7.54–17.57)]
9.6 (6.0–15.2), 60.2 (35.5–102.1)
1.0
Evans et al. (2002) [36]
Haimen City, China
Men and women (25–64 years),
Men 8795 HBsAg+ 49,659 HBsAg-
Women 2711 HBsAg+ 22,629 HBsAg-
643,257
61 16
18.8 (16.0–22.1) Adjusted for other factors
33.2 (17.0–65.0) Adjusted for other factors
Wang et al. (2003) [37]
Taiwan, China
Men (30–65 years),
2416 HBsAg+ 9421 HBsAg-
  13.1 (8.6–20.1)
Tanaka et al. (2004) [38]
Osaka, Japan
Blood donors (men and women 40–64 years),
2519 HBsAg+/ HCV- 1927 HCV+/ HBsAg-
25 HCV+ /HBsAg+ 150,379 HCV−/ HBsAg-
  74 (45–121) 36 (21–62)
161 (46–557) 1.0
Adjusted for sex, age, ALT level and cholesterol level.
Gwack et al. (2007) [39]
Korea
Men and women 30 +,
HBsAg+ 296 HBsAg- 6582
10 26 [9.6 (4.7–19.9)]
Amin et al. (2006) [44]
Australia
People notified as HBV or HCV positive to NSW State Health Department, All
39,109 HBsAg 75,834 HCV 2604 HBV/HCV Men 20,808 HBsAg 47,903 HCV 1932 HBV/HCV
Women 18,301 HBsAg 27,931 HCV 672 HBV/HCV
124,143 6
105,101 5
19 42 1
30.6 (25.7–36.5) 22.5 (19.1–26.5) 30.3 (13.6–67.5
30.6 (25.3–37.1) 18.7 (15.4–22.7) 27.5 (11.4–65.9)
30.7 (19.6–48.1) 44.0 (32.6–59.6) 64.2 (9.0–455.8)
Crook et al. (2003) [40]
England and Wales
Blood donors,
2681 HBsAg+ men 977 HBsAg+ women
National population rates as comparator
20 1 26 (16.0–40.5)
10 (NR)
Ribes et al. (2006) [41]
Spain
Blood donors,
1656 HBsAg+ men 631 HBsAg+ women
8783 HBsAg-men 6721 HBsAg-women
14 1 NR NR 14.1 (7.7–23.6)
1.5 (0.02–8.29)
  1. HCC, Hepatocellular carcinoma; RR, Relative risk