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Table 3 Cohort studies of HCV and lymphoid malignancies

From: Recognition criteria for occupational cancers in relation to hepatitis B virus and hepatitis C virus in Korea

Authors(Years), Country

Cohort description

Detection method,

No. of cases

Result

RR(95% CI)

Ohsawa et al. (1999) [95] Japan

2162 patients with HCV-related chronic hepatitis (1398 men, 834 women), admitted to 3 medical institutions in Osaka between 1957 and 1997; followed from date of diagnosis to 1997 (average follow-up: 5.7 years)

Anti-HCV,

[Obs:Exp]

B-cell NHL, 4:1.90

2.1 (0.57–5.4)

Adjusted age and calendar year

Rabkin et al. (2002) [117] USA

48,420 gravida, male partners,and offspring from 20,754 pregnancies, recruited from Kaiser Foundation Health Plan (California) between 1959

and 1966

Anti-HCV or HCVRNA,

B-cell NHL 0/57

MM 0/24

HD 0/14

No HCV+ controls

Duberg et al. (2005) [96] Sweden

27,150 HCV-infected persons notified to Swedish Institute for Infectious Disease Control

between 1990 and 2000 (19,147 men, 8003 women);

Anti-HCV

[Obs:Exp]

B-cell NHL 20:10.06

CLL 4:2.07

MM 7:2.89

2.0 (1.2–3.1)

1.9 (0.53–4.95)

2.4 (0.97–5.0),

Adjusted age, sex, and calendar year

Amin et al. (2006) [44]

New South Wales, Australia

75,834 HCV monoinfected (without HBV) persons notified to New South Wales Health Department’s Notifiable Diseases Database between 1990 and 2002 (47,903 men, 27,931 women); median age at viral hepatitis notification: 34 years; 10% of cohort estimated to be co-infected with HIV

[Anti-HCV+ or HCV RNA+],

NHL 33 FL 6

Diffuse NHL 19

T-cell NHL, 2 MM 7

HD 4

0.9 (0.6–1.2) 0.6 (0.3–1.4)

1.1 (0.7–1.7) 1.1 (0.3–-4.2)

0.8 (0.4–1.7) 0.4 (0.2–1.1)

Adjusted age, sex, and calendar year

UlcickasYood et al. (2007) [94] USA

Cohort of 3888 individuals with chronic HBV infection and comparison cohort of 205,203 individuals without HBV infection;

HCV laboratory test, NHL

Neg 116 Pos 3

1.0 2.4 (0.74–7.5),

Chronic HBV infection, sex, race and ethnicity, age, Charlson comorbidity score, median household income, and study site

Waters et al. (2005) [118] England

5823 HIV-positive patients at hospital in London, cohort followed since 1996 and seen at regular intervals for clinical assessment; anti-HCV testing

introduced in 1998:

Anti-HCV, NHL

Neg 56 Pos 7

Not tested 39

1.0

0.97 (0.44–2.1)

1.1 (0.71–1.6)

Franceschi et al. (2006b) [67]

Switzerland

Nested case–control study conducted within ongoing cohort study, enrolling people

infected with HIV since 1988 from 7 large hospitals in Switzerland; 298 cases of NHL with HCV serology and information on matching criteria occurred through 2004 (246 men, 52 women)

Anti-HCV, NHL

Neg 198 Pos 100

1.0 1.05 (0.63–1.75)

Adjusted centre, gender, age group, CD4+ count, HIV transmission category, and year of enrollment

  1. RR, Relative risk