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Table 3 Cohort studies of HCV and lymphoid malignancies

From: Recognition criteria for occupational cancers in relation to hepatitis B virus and hepatitis C virus in Korea

Authors(Years), Country Cohort description Detection method,
No. of cases
Result
RR(95% CI)
Ohsawa et al. (1999) [95] Japan 2162 patients with HCV-related chronic hepatitis (1398 men, 834 women), admitted to 3 medical institutions in Osaka between 1957 and 1997; followed from date of diagnosis to 1997 (average follow-up: 5.7 years) Anti-HCV,
[Obs:Exp]
B-cell NHL, 4:1.90
2.1 (0.57–5.4)
Adjusted age and calendar year
Rabkin et al. (2002) [117] USA 48,420 gravida, male partners,and offspring from 20,754 pregnancies, recruited from Kaiser Foundation Health Plan (California) between 1959
and 1966
Anti-HCV or HCVRNA,
B-cell NHL 0/57
MM 0/24
HD 0/14
No HCV+ controls
Duberg et al. (2005) [96] Sweden 27,150 HCV-infected persons notified to Swedish Institute for Infectious Disease Control
between 1990 and 2000 (19,147 men, 8003 women);
Anti-HCV
[Obs:Exp]
B-cell NHL 20:10.06
CLL 4:2.07
MM 7:2.89
2.0 (1.2–3.1)
1.9 (0.53–4.95)
2.4 (0.97–5.0),
Adjusted age, sex, and calendar year
Amin et al. (2006) [44]
New South Wales, Australia
75,834 HCV monoinfected (without HBV) persons notified to New South Wales Health Department’s Notifiable Diseases Database between 1990 and 2002 (47,903 men, 27,931 women); median age at viral hepatitis notification: 34 years; 10% of cohort estimated to be co-infected with HIV [Anti-HCV+ or HCV RNA+],
NHL 33 FL 6
Diffuse NHL 19
T-cell NHL, 2 MM 7
HD 4
0.9 (0.6–1.2) 0.6 (0.3–1.4)
1.1 (0.7–1.7) 1.1 (0.3–-4.2)
0.8 (0.4–1.7) 0.4 (0.2–1.1)
Adjusted age, sex, and calendar year
UlcickasYood et al. (2007) [94] USA Cohort of 3888 individuals with chronic HBV infection and comparison cohort of 205,203 individuals without HBV infection; HCV laboratory test, NHL
Neg 116 Pos 3
1.0 2.4 (0.74–7.5),
Chronic HBV infection, sex, race and ethnicity, age, Charlson comorbidity score, median household income, and study site
Waters et al. (2005) [118] England 5823 HIV-positive patients at hospital in London, cohort followed since 1996 and seen at regular intervals for clinical assessment; anti-HCV testing
introduced in 1998:
Anti-HCV, NHL
Neg 56 Pos 7
Not tested 39
1.0
0.97 (0.44–2.1)
1.1 (0.71–1.6)
Franceschi et al. (2006b) [67]
Switzerland
Nested case–control study conducted within ongoing cohort study, enrolling people
infected with HIV since 1988 from 7 large hospitals in Switzerland; 298 cases of NHL with HCV serology and information on matching criteria occurred through 2004 (246 men, 52 women)
Anti-HCV, NHL
Neg 198 Pos 100
1.0 1.05 (0.63–1.75)
Adjusted centre, gender, age group, CD4+ count, HIV transmission category, and year of enrollment
  1. RR, Relative risk