Fig. 2
Peripheral and cerebral oxygen saturation and Lake Louise Score in normobaric (hypoxic chamber; n = 7) and hypobaric (Little Matterhorn summit; n = 11) hypoxia. a Changes in pulse oximetry saturation (SpO2: %). b Changes in regional cerebral oxygen saturation (rScO2 % mean values of right and left hemisphere). Statistical analysis for A and B using one-way repeated-measures ANOVA with Greenhouse-Geisser correction, followed by multiple comparisons with Bonferroni correction. c Changes in Lake Louise Score (LLS: median and interquartile-range) for evaluation of Acute Mountain Sickness. Subjects completed a self-reported questionnaire on a tablet. Statistical analysis using Wilcoxon matched-pairs signed rank tests. d Comparison of regional cerebral oxygen saturation (rScO2: %; mean values of right and left hemisphere) between the four subjects with lowest LLS and the four subjects with highest LLS after 24 h in hypobaric hypoxia. Statistical analysis using t-test with Bonferroni-Sidak correction, difference between groups after exercise * p < 0.05, ** p < 0.01, *** p < 0.001 vs. baseline in Munich at 520 m; ° p < 0.05, °° p < 0.01, °°° p < 0.001 vs. prior time point