Table 1 Diagnostic criteria for systemic sclerosis (American College of Rheumatology/European League Against Rheumatism criteria for the classification of systemic sclerosis [23])

Skin thickening of the fingers of both hands extending proximal to the metacarpophalangeal joints (sufficient criterion)

●

●

Skin thickening of the fingers (only count the higher score)

Puffy fingers

●

●

Sclerodactyly of the fingers (distal to the metacarpophalangeal joints but proximal to the proximal

interphalangeal joints)

●

●

Fingertip lesions (only count the higher score)

Digital tip ulcers

●

●

Fingertip pitting scars

●

●

Telangiectasia

●

●

Abnormal nailfold capillaries

●

○

Pulmonary arterial hypertension and/or interstitial lung disease (maximum score is 2)

Pulmonary arterial hypertension

●

●

Interstitial lung disease

●

●

Raynaud’s syndrome

●

●

SSc-related autoantibodies (anti-centromere, anti– topoisomerase I [anti–Scl-70], anti–RNA polymerase III) (maximum score is 3)

Anti-centromere

N

N

Anti–topoisomerase I

●

●

Anti–RNA polymerase III

○

○