Single coronary artery originating from the right sinus Valsalva and ability to work
© De Rosa et al.; licensee BioMed Central. 2015
Received: 27 May 2014
Accepted: 9 January 2015
Published: 24 January 2015
We present a case of a 56-year-old male electrician who was admitted to the hospital with atrial fibrillation, atypical chest pain and dyspnea. He gave a history that on the morning he had working for almost 4 hours carrying out various activities with considerable physical effort. After cardioversion, conventional coronary angiography revealed a suspect of single coronary vessel (SCA) arising from the right sinus of Valsalva. The patient underwent multislice computed tomography that showed a SCA arising from the right sinus Valsalva and dividing in Right Coronary Artery (RCA) and Left Main coronary artery (LM). The finding of posterior course of the LM without atherosclerotic has proved crucial for the expression of an opinion of working capacity even with limitation.
The normal coronary circulation encompasses a wide spectrum of normal variants, which are often detected as incidental findings during coronary angiography (CAG). A single coronary artery ostium is a rare finding. In the general population, the incidence of single coronary artery is approximately 0.024% [1,2]. Clinically it may cause recurrent ischaemia, heart failure or sudden death. We introduce a case of an Journeyman electrician with average energy requirement for his working activity >6 Metabolic Equivalents of Task (METs), presenting with atrial fibrillation and chest pain after a morning of work.
A 56-year-old male electrician, with treated hypertension (reported mean values of blood pressure: 130/95 mm Hg), was admitted with chest pain lasting for about 60 minutes. He was journeymen electrician specialized in commercial, residential and low-voltage wiring.
He gave a history that on the morning he had working for almost 4 hours carrying out various activities such as manipulate cables and wires through cavities or carry boxes of electrical equipment weighing about 20 kilos, with considerable physical effort.
MSCT showed a SCA arising from the right sinus Valsalva and dividing in RCA and Left Main (LM) (Figure 1: panel B,C and D). The LM showed an acute take-off angle, turned posteriorly behind the aorta, reaching the atrio-ventricular groove where it divides into left anterior descending (LAD) and left circumflex (CX) arteries. No atherosclerotic plaque were present. The patient was discharged with only antihypertensive drug therapy. After 2 month, at follow up medical check, he reported no angina and no exertional dyspnea. His left ventricular ejection fraction was normal and exercise tolerance >12 METs. He returned to his full work duties, although we recommended him to avoiding strenuous work (under 6 METs) and work on overhead lines too.
Evaluating the capacity of a patient with coronary artery anomalies to carry out occupational work often poses a difficult problem for the physician. The reason for the difficulty is that many factors influence any recommendation regarding these patients’ return to work, and specific guidelines for these condition, due to the limited number of affected patients in working age, have not been critically evaluated.
In fact the overall incidence of coronary anomalies in humans is 0.6 to 1.3% out of which the single coronary artery originating from the right coronary sinus accounts for 1.3% of all coronary anomalies [4-7]. Concerning the course of a single coronary vessel arising from the right coronary sinus, four anatomical variants have been described according to the crossing of the LM to the left side of the heart: (1.) anterior: LM turns anteriorly in front of the right ventricular outflow tract; (2.) inter-arterial: LM lies between the great vessels, aorta and pulmonary artery; (3.) septal: LM has an intramyocardial septal course; (4.) posterior: LM turns posteriorly behind the aorta in infero-posterior direction [8-10]. The inter-arterial course has been known as cause of sudden cardiac death (>50%) . Other types can present with myocardial ischaemia, congestive heart failure and sudden cardiac death. Myocardial ischaemia is thought to occur due to the impaired coronary flow reserve and also secondary to the anatomic and functional anomaly of the ostium (acute aortocoronary angulation, slit-like ostium, ostial tissue flaps and initial course of the coronary artery within the aortic wall) . In the inter-arterial variant, ischaemia or sudden death are assumed to be caused by vascular compression or kinking [8,11,12]. Our case was the posterior variant judged as non-malignant anomaly without remarkable changes in cardiovascular risk [8,10]. It is very important to define the course of the coronary anomaly because some misinterpretations of the coronary angiography are possible. Therefore, additional nonivasive imaging methods with better spatial resolution like MSCT have been suggested [4,13-16]. Since the overall number of patients is small, the treatment strategy varies and is not clearly defined. Generally when an adult or older patient is incidentally diagnosed wrong sinus coronary malformations, in absence of coronary artery disease and in consideration that sudden death occurs at a young age, this occasional finding has likely no clinical significance and most probably needs no surgical therapy [17-19]. Nevertheless when these subjects are symptomatic, a clear guidelines have not yet been defined and the treatment is still controversial. The finding, in our case, of posterior course of the LM without atherosclerotic lesions has proved crucial to determine the therapeutic treatment with only antihypertensive drugs and to allow the patient to re-entry into the workforce even with suggestion to reduce the effort under 6 METs (as the transport of weights above 15 kilos) and to avoiding work on overhead lines too, although the patient reported that he had never worked on power lines [20,21].
In fact, in our case, although the anatomical variant has been classified as benign, the non-certain cause of high level of TnT and CK and the presence of atrial fibrillation after a strenuous work, maybe due to a coronary artery spasm associated with abnormal course of the coronary vessels, has led us to reduce the possible cardiovascular risks related to the professional activity of the patient.
In fact due to Haskell et al.  three major cardiac pathophysiologic processes due to ischemic heart disease in historical and clinical data of the patient may impair his physical working capacity: left ventricular dysfunction, myocardial ischemia and electrophysiologic disturbances as in our patient.
In conclusion in heart disease worker, the focus of physician is to determine whether or not the increase in cardiac demands produced by physical, psychological and environmental stressors will exceed the threshold for a “safe and sure working capacity” [23,24], especially when there are same anatomical anomaly that con influence this capacity.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images.
RDR was responsible for the radiological assessment. GR and CT was involved in the cardiological evaluation. DG and ML wrote the manuscript.
- Lipton MJ, Barry WH, Obrez I, Silverman JF, Wexler L. Isolated single coronary artery: diagnosis, angiographic classification, and clinical significance. Radiology. 1979;130:39–47.View ArticlePubMedGoogle Scholar
- Shirani J, Roberts WC. Solitary coronary ostium in the aorta in the absence of other major congenital cardiovascular anomalies. J Am Coll Cardiol. 1993;21:137–43.View ArticlePubMedGoogle Scholar
- Okamatsu K, Takano M, Sakai S, Ishibashi F, Uemura R, Takano T, et al. Elevated troponin T levels and lesion characteristics in non-ST-elevation acute coronary syndromes. Circulation. 2004;109(4):465–70.View ArticlePubMedGoogle Scholar
- Angelini P, Velasco JA, Flamm S. Coronary anomalies: incidence, pathophysiology and clinical relevance. Circulation. 2002;105:2449–54.View ArticlePubMedGoogle Scholar
- Liberthon RR, Dinsmore RE, Bharati S, Rubenstein JJ, Caufield J, Wheeler EO, et al. Aberrant coronary artery origin from the aorta: diagnosis and clinical significance. Circulation. 1974;50:774–9.View ArticleGoogle Scholar
- Yamanaka O, Hobbs RE. Coronary artery anomalies in 126595 patients undergoing coronary angiography. Cathet Cardiovasc Diagn. 1990;21:28–40.View ArticlePubMedGoogle Scholar
- Chaitman BR, Lesperance J, Saltiel J, Bourassa MG. Clinical, angiographic, and hemodynamic findings in patients with anomalous origin of the coronary arteries. Circulation. 1976;53:122–31.View ArticlePubMedGoogle Scholar
- Taylor AJ, Byers JP, Cheitlin MD, Virmani R. Anomalous right or left coronary artery from the contralateral coronary sinus: “high risk” abnormalities in the initial coronary artery course and heterogeneous clinical outcomes. Am Heart J. 1997;133:428–35.View ArticlePubMedGoogle Scholar
- Ishikawa T, Brandt CW. Anomalous origin of the left main coronary artery from the right anterior aortic sinus. Angiographic definition of anomalous course. Am J Cardiol. 1985;55:770–6.View ArticlePubMedGoogle Scholar
- Kimbris D, Iskandrian AS, Segal BL, Bemis CE. Anomalous aortic origin of coronary arteries. Circulation. 1978;58:606–15.View ArticleGoogle Scholar
- Karamichalis JM, Vricella LA, Murphy DJ, Reitz BA. Simplified technique for correction of anomalous origin of left coronary artery from the anterior aortic sinus. Ann Thorac Surg. 2003;76:266–7.View ArticlePubMedGoogle Scholar
- Taylor AJ, Rogan KM, Virmani R. Sudden cardiac death associated with isolated congenital coronary artery anomalies. J Am Coll Card. 1992;20:640–7.View ArticleGoogle Scholar
- Ropers D, Moshage W, Werner GD, Jessl J, Gottwik M, Achenbach S. Visualisation of coronary artery anomalies and their anatomic course by contrast-enhanced electron beam tomography and three dimensional reconstruction. American J Cardiol. 2001;87:193–7.View ArticleGoogle Scholar
- Tedeschi C, Briguori C, De Rosa R, Ratti G, Cademartiri F, Sacco M, et al. Right coronary artery arising from pulmonary trunk: assessment with conventional coronary angiography and multislice computed tomography coronary angiography. J Cardiovasc Med (Hagerstown). 2009;10(2):178–82. doi:10.2459/JCM.0b013e32831de545.View ArticleGoogle Scholar
- Khouzam R, Marshall T, Lowell D, Siler JR. Left coronary artery originating from right sinus of Valsalva, with diagnosis confirmed by CT. Angiology. 2003;54:499–502.View ArticlePubMedGoogle Scholar
- di Cesare E, Carbone I, Carriero A, Centonze M, De Cobelli F, De Rosa R, et al. Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radiology (SIRM). Clinical indications for cardiac computed tomography. From the Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radiology (SIRM). Radiol Med. 2012;117(6):901–38.View ArticlePubMedGoogle Scholar
- Wolf T, Bolotin G, Ammar R, Uretzky G. Anomalous origin of the left main coronary artery and concomitant LIMA to LAD grafting. Eur J Card Thorac Surg. 1999;15:209–12.View ArticleGoogle Scholar
- LaBorde F, Marchand M, Leca F, Jarreau MM, Dequirot A, Hazen E. Surgical treatment of anomalous origin of left coronary artery in infancy and childhood. Early and late results in twenty consecutive cases. J Thorac Cardivasc Surg. 1981;82:423–8.Google Scholar
- Pelliccia A. Congenital coronary artery anomalies in young patients: New perspectives for timely identification. J Am Coll Cardiol. 2001;37:598–600.View ArticlePubMedGoogle Scholar
- Zanettini R, Farina G. Work capacity and re-entry into the workforce for the cardiac patient. Med Lav. 2004;95:140–4.PubMedGoogle Scholar
- Wolf R, Habel F, Heiermann M, Jäkel R, Sinn R. Cardiac risk of coronary patients after reintegration into occupations with heavy physical exertion. Z Kardiol. 2005;94(4):265–73.View ArticlePubMedGoogle Scholar
- Haskell WL, Brachfeld N, Bruce RA, Davis PO, Dennis CA, FOX III SM, et al. Determination of occupational working capactiy in patients with ischemic heart disease. I. Am Coll Cardiol. 1989;14:1034–225.View ArticleGoogle Scholar
- Lamberti M, Ratti G, Di Miscio G, Franciolini E, Piancone M, Capogrosso C, et al. Cardiovascular Risk in Young Workers with Left Bundle Branch Block. OJPM. 2014; 4, 270–274.http://dx.doi.org/10.4236ojpm. 2014. 45033.
- De Rosa R, Ratti G, Lamberti M. Onset of recent exertional dyspnoea in a firefighter with left bundle-branch block. BMJ Case Rep. 2014;28:2014. pii:bcr2014207424. doi:10.1136/bcr-2014-207424.Google Scholar
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